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T-cell receptor excision circles
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T-cell receptor excision circles : ウィキペディア英語版
T-cell receptor excision circles
T-cell receptor excision circles (TRECs) are small circles of DNA created in T-cells during their passage through the thymus as they rearrange their TCR genes.〔http://allergycases.org/2010/05/t-cell-receptor-excision-circles-trecs.html 〕 Their presence indicates maturation of T cells;
TRECs are reduced in SCID (Severe combined immunodeficiency disease).
Single joint T-cell receptor excision circles (sjTRECs) were
in the news as a way to test the age of the individual from a blood sample.〔 (telegraph.co.uk )〕 The detection of sjTRECs can be further used as a diagnostic tool to monitor the thymic output e.g. following hematopoietic stem cell transplantation or in case of AIDS 〔http://www.ncbi.nlm.nih.gov/pubmed/?term=Detection+of+T+cell+receptor+circles+(TRECs)+as+biomarkers+for+de+novo+T+cell+synthesis+using+a+quantitative+polymerase+chain+reaction–enzyme+linked+immunosorbent+assay+(PCR–ELISA) 〕
==See also==

* T cell receptor
* V(D)J recombination

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「T-cell receptor excision circles」の詳細全文を読む



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